ATC Code C02AC06
Formula C10H16N2O
Molar Mass (g·mol−1) 180.251
Physical State solid
CAS Number 54187-04-1
PUB Number 68712
Drugbank ID DB11738
Solubility moderate in water / poor in ethanol


Rilmenidine is a centrally acting antihypertensive and also belongs to the group of sympatholytics. It is used to treat essential hypertension (high blood pressure), often in combination with other antihypertensives.

Rilmendidine requires a prescription and is usually taken in tablet form.



Rilmenidine binds to certain receptors in the brain and in the periphery, especially in the kidney. This inhibits sympathetic activity, resulting in lower blood pressure.


Rilmenidine is absorbed through the gastrointestinal tract. Plasma protein binding is only about 7% and the elimination half-life is about 8 hours. Rilmenidine is not cleared in the liver but is excreted unchanged by the kidneys.

Drug Interactions

Rilmenidine should not be taken in combination with MAO inhibitors and tricyclic antidepressants.


No overdoses have been observed so far. Signs of a possible overdose are probably low blood pressure, fatigue and tiredness.

Side effects

Possible unwanted side effects are anxiety, depression, insomnia, drowsiness, dizziness, palpitations, drowsiness, cold hands and feet, appearance of tissue swelling (edema), headache, pain in the upper abdomen, dry mouth, diarrhea, constipation, itching, skin rash, muscle cramps, sexual dysfunction, general body weakness, fatigue on exertion.

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All information used for the content comes from verified sources (recognised institutions, experts, studies by renowned universities). We attach great importance to the qualification of the authors and the scientific background of the information. Thus, we ensure that our research is based on scientific findings.

Markus Falkenstätter

Markus Falkenstätter

Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.

Mag. pharm Stefanie Lehenauer

Mag. pharm Stefanie Lehenauer

Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.

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