| ATC Code | C02AC06 |
| CAS number | 54187-04-1 |
| PUB number | 68712 |
| Drugbank ID | DB11738 |
| Empirical formula | C10H16N2O |
| Molar mass (g·mol−1) | 180.251 |
| Physical state | solid |
Rilmenidine is a centrally acting antihypertensive and also belongs to the group of sympatholytics. It is used to treat essential hypertension (high blood pressure), often in combination with other antihypertensives.
Rilmendidine requires a prescription and is usually taken in tablet form.
Rilmenidine binds to certain receptors in the brain and in the periphery, especially in the kidney. This inhibits sympathetic activity, resulting in lower blood pressure.
Rilmenidine is absorbed through the gastrointestinal tract. Plasma protein binding is only about 7% and the elimination half-life is about 8 hours. Rilmenidine is not cleared in the liver but is excreted unchanged by the kidneys.
Rilmenidine should not be taken in combination with MAO inhibitors and tricyclic antidepressants.
No overdoses have been observed so far. Signs of a possible overdose are probably low blood pressure, fatigue and tiredness.
Possible unwanted side effects are anxiety, depression, insomnia, drowsiness, dizziness, palpitations, drowsiness, cold hands and feet, appearance of tissue swelling (edema), headache, pain in the upper abdomen, dry mouth, diarrhea, constipation, itching, skin rash, muscle cramps, sexual dysfunction, general body weakness, fatigue on exertion.
Markus Falkenstätter, BSc
Mag. pharm. Stefanie Lehenauer
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