| ATC Code | R03AC12 |
| CAS number | 89365-50-4 |
| PUB number | 5152 |
| Drugbank ID | DB00938 |
| Empirical formula | C25H37NO4 |
| Molar mass (g·mol−1) | 415,57 |
| Physical state | solid |
| Melting point (°C) | 75,5–76,5 |
| PKS value | 11.2 |
Salmeterol is a long-acting beta-2-adrenoreceptor agonist currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD. It has a longer duration of action than the short-acting beta-2-adrenoreceptor agonist salbutamol. Salmeterol is only available as an antiasthmatic agent for inhalation and requires a prescription.
Salmeterol is a long-acting beta-2-adrenoceptor agonist. Stimulation of the beta-2-adrenoceptor causes bronchial smooth muscle relaxation, bronchodilation, and improved airflow.
Salmeterol is 96% bound to albumin and alpha-1-acid glycoprotein in plasma. Salmeterol is metabolized predominantly by CYP3A4 to alpha-hydroxysalmeterol and to a lesser extent by an unknown mechanism to an O-dealkylated metabolite. Salmeterol is excreted 57.4% in feces and 23% in urine. Less than 5% of a dose is excreted in the urine as unchanged salmeterol. The half-life of salmeterol is 5.5 hours.
Because of its vasodilator properties, the most common side effects of salmeterol are
Other side effects
Certain side effects should be reported to a doctor or health care professional right away. Some of these more serious side effects include
LD50 (rat, oral): > 1000 mg-kg-1
Markus Falkenstätter, BSc
Mag. pharm. Stefanie Lehenauer
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