Sarolan

Sarolan
Formula C23H18Cl2F4N2O5
Molar Mass (g·mol−1) 581,4
CAS Number 1398609-39-6
PUB Number 73169092

Basics

Sarolaner is an isoxazoline used for the treatment of flea, tick or mite infestation in dogs due to its antiparasitic mode of action. The veterinary drug is marketed under the trade name Simparica® and has been approved in the EU since 2015 and in Switzerland since 2017 in the form of chewable tablets.
Der Wirkstoff verhindert eine Umweltkontamination mit Flöhen, da es die Flöhe vor der Eierlegung abtötet.

Pharmacology

Pharmacodynamics

The mechanism of action of Sarolaner is based on blockade of GABA- and glutamate-gated chloride channels. Disruption of GABA and glutamate receptors inhibits the uptake of chloride ions into the central nervous system of mites and insects, resulting in increased nerve stimulation. This ultimately causes the death of the parasites.
Innerhalb von 28 Tagen nach der Gabe des Medikaments tritt die Wirkung bei Flöhen innerhalb von 8 Stunden nach der Anheftung ein, bei Zecken innerhalb von 12 Stunden nach der Anheftung. Zecken, die sich schon vor der Verabreichung auf dem Tier befanden, werden innerhalb von 24 Stunden abgetötet.

Pharmacokinetics

Sarolaner has a high bioavailability of 85%. The drug circulates almost completely bound to plasma proteins. The half-life is approximately 11 to 12 hours. It is excreted in the feces.

Drug Interactions

There are no known interactions with other active ingredients.

Toxicity

Toxicological data

Transient neurological signs, such as mild tremor and convulsions, were observed in some pups at 3 to 5 times the maximum treatment dose of 4 mg/kg, but the animals recovered without treatment.

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Markus Falkenstätter

Markus Falkenstätter
Author

Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.

Mag. pharm Stefanie Lehenauer

Mag. pharm Stefanie Lehenauer
Lector

Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.

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