Sodium fluoride

Sodium fluoride
ATC Code A01AA01, A12CD01
Molar Mass (g·mol−1) 41,99
Physical State solid
Density (g·cm−3) 2,78
Melting Point (°C) 993
Boiling Point (°C) 1704
CAS Number 7681-49-4
PUB Number 5235
Solubility moderate in water / poor in ethanol


The colorless sodium fluoride crystallizes in the sodium chloride structure and can be "grown" into single crystals. It is transparent to infrared and UV light. It is only moderately soluble in water at all temperatures. Heating hardly increases the solubility. It does not dissolve in ethanol. In concentrated sulfuric acid it converts to sodium sulfate and hydrogen fluoride. As a result of partial hydrolysis, the aqueous solution of sodium fluoride reacts slightly alkaline. Sodium fluoride acts as an insecticide and is toxic.


The protective effect of sodium fluoride on dental and oral health is explained in two ways. On the one hand, the active ingredient is incorporated into the tooth enamel, making it more resistant. Secondly, it is assumed that sodium fluoride also directly reduces the bacterial load in the oral cavity. It is not clear how this effect is achieved.

In the prevention and treatment of osteoporosis, the fact that sodium fluoride has a stimulating effect on the bone-forming osteoblasts is exploited. In addition, the active substance is incorporated into the bone structure and thus improves bone density.


Sodium fluoride is toxic. Avoid inhalation of dusts. Gloves must be worn when working with sodium fluoride. An amount of 5-10 g for a 70 kg person is generally considered lethal. However, deaths have been observed at doses as low as 15 mg/kg, which corresponds to 1.05 g of sodium fluoride for a 70 kg person. For these reasons, an amount of 5 mg/kg is already considered to be a critical threshold, since serious life-threatening symptoms of poisoning may already occur from this point onwards, requiring immediate emergency treatment.

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Markus Falkenstätter

Markus Falkenstätter

Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.

Mag. pharm Stefanie Lehenauer

Mag. pharm Stefanie Lehenauer

Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.

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