ATC Code A02BX02
Formula C12H54Al16O75S8
Molar Mass (g·mol−1) 2086,74
Physical State solid
Melting Point (°C) 130
PKS Value 0.43-1.19
CAS Number 54182-58-0
PUB Number 121494085
Drugbank ID DB00364
Solubility soluble in dilute hydrochloric acid and caustic soda, insoluble in water and ethanol


Sucralfate is a drug used to treat a number of different conditions affecting the gastrointestinal tract. These include the treatment of ulcerations in the stomach and intestines, symptomatic treatment of reflux disease and dyspepsia. This drug is an aluminum salt of sucrose sulfate.

Sucralfate is available by prescription only and is most commonly available as a tablet or suspension.



Sucralfate acts by binding proteins, pesin and bile acids. This forms a protective film over the ulcerations and the gastric mucosa. In addition, prostagalndins and growth factors are produced and mucus production is increased. This relieves inflammation and supports the healing process.

The exact mechanism of action is based on the complex formation between sucralfate and proteins from the exudate of the ulcerations. This forms a protective film that protects the mucous membrane from the protons of gastric acid (hydrochloric acid). Exactly how sucralfate increases the level of growth factors and mucus production is not yet fully understood.


Sucralfate is absorbed only in extremely small amounts and acts mainly locally. This drug contains aluminum, which can be absorbed into the body in very small amounts. In patients with reduced renal function, this amount may be higher. The main part of the ingested dose is excreted unchanged.

Drug interactions

Sucralfate increases the pH in the stomach, therefore some drugs may be less well absorbed. These include beta blockers, antibiotics, digitalis glycosides, theophylline and vitamin B12.


No overdoses with sucralfate have been observed to date.

There is no evidence that sucralfate is teratogenic or carcinogenic.

Side effects

The most common side effect is the occurrence of constipation. Occasionally, nausea and dry mouth may occur.

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All information used for the content comes from verified sources (recognised institutions, experts, studies by renowned universities). We attach great importance to the qualification of the authors and the scientific background of the information. Thus, we ensure that our research is based on scientific findings.

Markus Falkenstätter

Markus Falkenstätter

Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.

Mag. pharm Stefanie Lehenauer

Mag. pharm Stefanie Lehenauer

Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.

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