| ATC Code | J01CG02 |
| CAS number | 89786-04-9 |
| PUB number | 123630 |
| Drugbank ID | DB01606 |
| Empirical formula | C10H12N4O5S |
| Molar mass (g·mol−1) | 300,30 |
| Physical state | solid |
| Melting point (°C) | > 170 |
| PKS value | 2,1 |
Tazobactam is a pharmaceutical agent that inhibits the action of bacterial β-lactamases. It is commonly used as its sodium salt, tazobactam sodium. The drug is added to certain antibiotics to make them less susceptible to antimicrobial resistance in bacteria. Tazobactam is commonly given with the β-lactam antibiotic piperacillin, which is used for infections caused by Pseudomonas aeruginosa.
Tazobactam broadens the spectrum of piperacillin by making it effective against organisms that express beta-lactamase and would normally degrade it. It does this by irreversibly inhibiting beta-lactamase enzymes.
Maximum plasma concentrations occur immediately after intravenous infusion. Tazobactam is approximately 30% bound to plasma proteins. Tazobactam and its metabolite are excreted primarily by the kidneys, with approximately 80% of the administered dose excreted as unchanged drug. The plasma half-life is approximately 1 hour.
LD50 (rat, oral): > 5000 mg-kg-1
Markus Falkenstätter, BSc
Mag. pharm. Stefanie Lehenauer
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