Tazobactam

Tazobactam
ATC Code J01CG02
Formula C10H12N4O5S
Molar Mass (g·mol−1) 300,30
Physical State solid
Melting Point (°C) > 170
PKS Value 2,1
CAS Number 89786-04-9
PUB Number 123630
Drugbank ID DB01606
Solubility soluble in water

Basics

Tazobactam is a pharmaceutical agent that inhibits the action of bacterial β-lactamases. It is commonly used as its sodium salt, tazobactam sodium. The drug is added to certain antibiotics to make them less susceptible to antimicrobial resistance in bacteria. Tazobactam is commonly given with the β-lactam antibiotic piperacillin, which is used for infections caused by Pseudomonas aeruginosa.

Pharmacology

Pharmacodynamics

Tazobactam broadens the spectrum of piperacillin by making it effective against organisms that express beta-lactamase and would normally degrade it. It does this by irreversibly inhibiting beta-lactamase enzymes.

Pharmacokinetics

Maximum plasma concentrations occur immediately after intravenous infusion. Tazobactam is approximately 30% bound to plasma proteins. Tazobactam and its metabolite are excreted primarily by the kidneys, with approximately 80% of the administered dose excreted as unchanged drug. The plasma half-life is approximately 1 hour.

Toxicity

Toxicological data

LD50 (rat, oral): > 5000 mg-kg-1

Sources

  • Drugbank
  • PubChem
  • Aktories, Förstermann, Hofmann, Starke: Allgemeine und spezielle Pharmakologie und Toxikologie, Elsvier, 2017

Editorial principles

All information used for the content comes from verified sources (recognised institutions, experts, studies by renowned universities). We attach great importance to the qualification of the authors and the scientific background of the information. Thus, we ensure that our research is based on scientific findings.

Markus Falkenstätter

Markus Falkenstätter
Author

Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.

Mag. pharm Stefanie Lehenauer

Mag. pharm Stefanie Lehenauer
Lector

Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.

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