Tazobactam

ATC CodeJ01CG02
CAS number89786-04-9
PUB number123630
Drugbank IDDB01606
Empirical formulaC10H12N4O5S
Molar mass (g·mol−1)300,30
Physical statesolid
Melting point (°C)> 170
PKS value2,1

Basics

Tazobactam is a pharmaceutical agent that inhibits the action of bacterial β-lactamases. It is commonly used as its sodium salt, tazobactam sodium. The drug is added to certain antibiotics to make them less susceptible to antimicrobial resistance in bacteria. Tazobactam is commonly given with the β-lactam antibiotic piperacillin, which is used for infections caused by Pseudomonas aeruginosa.

Pharmacology

Pharmacodynamics

Tazobactam broadens the spectrum of piperacillin by making it effective against organisms that express beta-lactamase and would normally degrade it. It does this by irreversibly inhibiting beta-lactamase enzymes.

Pharmacokinetics

Maximum plasma concentrations occur immediately after intravenous infusion. Tazobactam is approximately 30% bound to plasma proteins. Tazobactam and its metabolite are excreted primarily by the kidneys, with approximately 80% of the administered dose excreted as unchanged drug. The plasma half-life is approximately 1 hour.

Toxicity

Toxicological data

LD50 (rat, oral): > 5000 mg-kg-1

Sources

  • Drugbank
  • PubChem
  • Aktories, Förstermann, Hofmann, Starke: Allgemeine und spezielle Pharmakologie und Toxikologie, Elsvier, 2017
Markus Falkenstätter, BSc

Markus Falkenstätter, BSc

Mag. pharm. Stefanie Lehenauer

Mag. pharm. Stefanie Lehenauer



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