| ATC Code | A01AB13, D06AA04, D10AF08, J01AA07, S01AA09, S02AA08, S03AA02 |
| CAS number | 60-54-8 |
| PUB number | 54675776 |
| Drugbank ID | DB00759 |
| Empirical formula | C22H24N2O8 |
| Molar mass (g·mol−1) | 444,44 |
| Physical state | solid |
| Melting point (°C) | 172 |
| PKS value | 3.3 |
Tetracycline is a broad-spectrum antibiotic produced by the Streptomyces genus of actinobacteria. It has a bacteriostatic effect on a wide range of gram-positive and gram-negative pathogens. It is used to treat a number of infections. These include acne, cholera, brucellosis, plague, malaria, and syphilis. It is taken by mouth. Tetracycline requires a prescription and is on the World Health Organization's list of essential medicines.
Tetracycline passively diffuses through pore channels in the bacterial membrane and reversibly binds to the 30S ribosomal subunit, preventing tRNA binding to the mRNA-ribosome complex and thus interfering with protein synthesis. As a result, bacteria are unable to proliferate further and can be more easily eliminated by the immune system.
Bioavailability is less than 40% with intramuscular administration, 100% intravenously, and 60-80% orally (fasting adults). Food and/or milk reduce GI absorption of oral tetracycline preparations by 50% or more. Plasma protein binding is approximately 20-70%. Excretion is by the kidney and the half-life is 6-12 hours.
Tetracycline may be inactivated by iron, aluminum or calcium. Therefore, dairy products, iron supplements, and antacids should be avoided while taking it.
LD50 (mouse,oral): 678 mg-kg-1
Markus Falkenstätter, BSc
Mag. pharm. Stefanie Lehenauer
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