Thiocolchicoside is a muscle relaxant with anti-inflammatory and analgesic effects. Thiocolchicoside is a semisynthetic derivative of colchicine, a natural anti-inflammatory substance extracted from the flower seeds of the autumn crocus (Colchicum autumnale). The substance is used to treat orthopedic, traumatic, and rheumatologic conditions. It is also used as an adjuvant in the treatment of painful muscle contractions and acute spinal disorders in adults and adolescents 16 years of age and older.
Due to its pronounced and sometimes serious side effects, the EMA (European medicines agency) recommends thiocolchicoside only as an adjuvant in acute muscle spasms and advises against longer-term treatment.