Loop diuretics, including torsemide, may decrease total body thiamine levels, especially in individuals with poor thiamine intake. This thiamine deficiency can worsen heart failure. It is therefore reasonable to either administer additional thiamine supplements or monitor blood thiamine levels in individuals treated with chronic loop diuretics.
Common side effects include headache, increased urination, diarrhea, cough, and dizziness. Other side effects may include hearing loss and low blood potassium and magnesium. Torasemide is a sulfonamide and therefore may cause allergic reactions. There may be uric acid retention, which promotes a gout attack. Furthermore, a decreased glucose tolerance occurs.
Use during pregnancy or lactation is not recommended.
- Renal failure
- severe hepatic insufficiency
LD50 (rat, oral): > 5000 mg-kg-1