Trospium

Trospium
ATC Code A03AB20, G04BD09
Formula C25H30NO3+
Molar Mass (g·mol−1) 392,518
Physical State solid
Melting Point (°C) 255-257
CAS Number 47608-32-2
PUB Number 5284632
Drugbank ID DB00209

Basics

Trospium or its chloride salt is an antispasmodic drug used to treat the symptoms of hyperactive bladder. It belongs to the group of parasympatholytics. The active ingredient is commercially available in coated tablet form.

Pharmacology

Pharmacodynamics

Trospium inhibits the neurotransmitter acetylcholine, which controls the state of tension in many organs. The antispasmodic properties of the active ingredient cause relaxation of the urinary bladder wall muscles and tension of the bladder sphincter. This improves symptoms such as urinary incontinence, urinary urgency and frequent urination.

Pharmacokinetics

Due to its hydrophobic state, the drug hardly passes the blood-brain barrier and therefore shows practically no adverse effects on the central nervous system.
Die Aufnahme in den Organismus beträgt nur 9,6% und zirkuliert zu 50-85% proteingebunden. Trospium hat eine Halbwertzeit von 20 Stunden. Die Ausscheidung erfolgt hauptsächlich über den Stuhl.

Contraindications

The agent should not be used in the following conditions:

  • Urinary retention
  • Untreated glaucoma
  • Benign enlargement of the prostate
  • Myasthenia gravis (neuromuscular autoimmune disease)
  • Cardiac arrhythmias
  • Pyloric stenosis (narrowing of the gastric outlet)
  • Chronic inflammatory bowel disease and megacolon
  • Renal insufficiency requiring dialysis

Toxicity

Side effects

The most common side effects include:

  • Dry mouth
  • Skin redness
  • decreased perspiration
  • Blurred vision
  • bloating, constipation
  • Abdominal pain
  • Nausea

Toxicological data

LD50 (mouse, oral): 812 mg/kg
LD50 (Maus, intravenös): 11,2 mg/kg

Editorial principles

All information used for the content comes from verified sources (recognised institutions, experts, studies by renowned universities). We attach great importance to the qualification of the authors and the scientific background of the information. Thus, we ensure that our research is based on scientific findings.

Markus Falkenstätter

Markus Falkenstätter
Author

Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.

Mag. pharm Stefanie Lehenauer

Mag. pharm Stefanie Lehenauer
Lector

Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.

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