Do not take ENCAPIA
- if you are allergic to entacapone or any of the other ingredients of this medicine (listed in section 6).;
- if you have a tumour of the adrenal gland (known as pheochromocytoma; this may increase the risk of severe high blood pressure);
- if you are taking certain antidepressants (ask your doctor or pharmacist whether your antidepressive medicine can be taken together with ENCAPIA);
- if you have liver disease;
- if you have ever suffered from a rare reaction to antipsychotic medicines called neuroleptic malignant syndrome (NMS). See section 4 Possible side effects for the characteristics of NMS;
- if you have ever suffered from a rare muscle disorder called rhabdomyolysis which was not caused by injury.
Warnings and precautions
Talk to your doctor if any of the following applies to you:
- if you have ever had a heart attack or any other diseases of the heart
- if you are taking a medicine which may cause dizziness or light-headedness (low blood pressure) when rising from a chair or bed;
- if you experience prolonged diarrhoea consult your doctor as it may be a sign of inflammation of the colon
- if you experience diarrhoea, monitoring of your weight is recommended in order to avoid potentially excessive weight loss;
- if you experience increasing loss of appetite, weakness, exhaustion and weight loss within a relatively short period of time, a general medical evaluation including liver function should be considered.
As ENCAPIA tablets will be taken together with other levodopa medicines, please also read the package leaflets of these medicines carefully.
The dose of other medicines to treat Parkinson’s disease may need to be adjusted when you start taking
ENCAPIA. Follow the instructions that your doctor has given you.
Neuroleptic Malignant Syndrome (NMS) is a serious but rare reaction to certain medicines, and may occur especially when ENCAPIA and other medicines to treat Parkinson’s disease are suddenly stopped or the dose is suddenly reduced. For the characteristics of NMS see Section 4 Possible side effects. Your doctor may advise you to slowly discontinue the treatment with ENCAPIA and other medicines to treat Parkinson’s disease.
ENCAPIA taken with levodopa may cause drowsiness and may cause you to sometimes suddenly fall asleep. If this happens, you should not drive or use any tools or machines (see Driving and using machines).
Tell your doctor if you or your family/carer notices you are developing urges or cravings to behave in ways that are unusual for you or you cannot resist the impulse, drive or temptation to carry out certain activities that could harm yourself or others. These behaviours are called impulse control disorders and can include
addictive gambling, excessive eating or spending, an abnormally high sex drive or an increase in sexual thoughts or feelings. Your doctor may need to review your treatments.
Other medicines and ENCAPIA
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. In particular please tell your doctor if you are taking any of the following:
- rimiterole, isoprenaline, adrenaline, noradrenaline, dopamine, dobutamine, alphamethyldopa, apomorphine;
- antidepressants including desipramine, maprotiline, venlafaxine, paroxetine;
- warfarin used to thin the blood;
- iron supplements. ENCAPIAmay make it harder for you to digest iron. Therefore, do not take ENCAPIA and iron supplements at the same time. After taking one of them, wait at least 2 to 3 hours before taking the other.
Pregnancy,breast-feeding and fertility
Do not use ENCAPIA during pregnancy or if you are breast-feeding.
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.
Driving and using machines
ENCAPIA taken together with levodopa may lower your blood pressure, which may make you feel light- headed or dizzy. Be particularly careful when you drive or when you use tools or machinery.
In addition, ENCAPIA taken with levodopa may make you feel very drowsy, or cause you to sometimes suddenly fall asleep.
Do not drive or operate machinery if you experience these side effects.