Do not use Prolia
- if you have low calcium levels in the blood (hypocalcaemia).
- if you are allergic (hypersensitive) to denosumab or any of the other ingredients of Prolia.
Take special care with Prolia
Please tell your doctor immediately if you develop a swollen, red area of skin, most commonly in the lower leg, that feels hot and tender (cellulitis), and possibly with symptoms of fever while being on treatment with Prolia.
Tell your doctor if you have or have ever had severe kidney problems, kidney failure or have needed dialysis.
You should also take calcium and vitamin D supplements while being on treatment with Prolia. Your doctor will discuss this with you.
A dental examination should be considered before you start treatment with Prolia if you have cancer, are undergoing chemotherapy or radiotherapy, are taking steroids, do not receive routine dental care or have gum disease.
If you are under dental treatment or will undergo dental surgery, tell your dentist that you are being treated with Prolia.
It is important to maintain good oral hygiene when being on treatment with Prolia.
Prolia is not recommended for anyone under 18 years of age. The use of Prolia in children and adolescents has not been studied.
Using other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
Pregnancy and breast-feeding
Prolia has not been tested in pregnant women. It is important to tell your doctor if you are pregnant; think you may be pregnant; or plan to get pregnant. Prolia is not recommended for use if you are pregnant.
It is not known whether Prolia is excreted in breast milk. It is important to tell your doctor if you are breast-feeding or plan to do so. Your doctor will then help you decide whether to stop breast-feeding, or whether to stop taking Prolia, considering the benefit of breast-feeding to the baby and the benefit of Prolia to the mother.
Ask your doctor or pharmacist for advice before taking any medicine.
Driving and using machines
Prolia has no or negligible influence on the ability to drive and use machines
Important information about some of the ingredients of Prolia
If you have an intolerance to some sugars
If you have been told by your doctor that you have an intolerance to some sugars (sorbitol E420), contact your doctor before taking this medicinal product.
If you are on a controlled sodium diet
This medicinal product contains less than 1 mmol sodium (23 mg) per 60 mg, i.e. essentially ?sodium-free?.