Like all medicines, Refludan can have side effects although not everybody gets them.
Very common (at least 1 in 10 people)
Reported bleeding events include: anaemia or drop in the haemoglobin value without obvious source of bleeding, bruising, bleeding from puncture sites, nose bleeding,blood in urine , gastrointestinal bleeding, vaginal bleeding, rectal bleeding, pulmonary haemorrhage, bleeding into chest space and around the heart following surgery , bleeding into the brain.
Severe bleeding and, in particular, intracranial bleeding may be fatal. In intensified post-marketing surveillance in HIT type II, fatal bleeding was reported in 1 % and intracranial bleeding in 0.2 % of patients. Severe bleeding may lead to decreased volume of circulating blood , low blood pressure , shock, and their clinical sequelae.
Rare (less than 1 in 1,000 people affected)
? Allergic skin reactions (including rash), itching , hot flushes, fever, chills.
Anaphylacticoid reactions including urticaria, difficulty in breathing e.g. consisting of spasms, cough, sharp sound when breathing, build-up of water in the body and in the inner wall of a vessel including face oedema, tongue oedema, throat oedema. In severe cases these may lead to shock and death. Injection site reactions, including pain.
If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.