| ATC Code | D07AC06, D07XC04 |
| CAS number | 2607-06-9 |
| PUB number | 11954369 |
| Drugbank ID | DB09095 |
| Empirical formula | C22H28F2O4 |
| Molar mass (g·mol−1) | 394,459 |
| Physical state | solid |
| Melting point (°C) | 220 |
| Boiling point (°C) | 534 |
Diflucortolone is a steroid hormone from the group of glucocorticoids, which is used for external application in the symptomatic treatment of inflammatory skin diseases (e.g. neurodermatitis, eczema of the face, psoriasis) or as an additional therapy for dermatomycoses. However, the corticosteroid must not be used for the treatment of viral, bacterial or parasitic diseases of the skin.
Im Handel wird der Wirkstoff als Creme oder Salbe vertrieben.
The anti-inflammatory, antipruritic and vasoconstrictor effects are due to the constriction of blood vessels, which reduces the release of inflammatory substances. This effect causes soothing of the skin and reduces mucosal swelling and mucus secretion.
Diflucortolon bindet in der Zelle an Glukokortikoid-Rezeptoren, gelangt als Komplex in den Zellkern und hemmt dort die Bildung verschiedener Zytokine (Proteine). Dadurch wird die Synthese der Arachidonsäure (Fettsäure) blockiert, wodurch wiederum die Bildung, Freisetzung und Aktivität von Entzündungsmediatoren verhindert wird.
Absorption is percutaneous, i.e. through the skin, and bioavailability depends on the formulation of the drug, as well as the dose, treatment duration, condition and range. Less than 1% of the administered dose enters the bloodstream, which is subsequently distributed to various organs and tissues. Degradation occurs in the liver and is relatively rapid, as is elimination. The half-life of diflucortolone is approximately 4 to 5 hours.
In addition to viral and bacterial infections, diflucortolone should not be used in vaccination reactions, perioral dermatitis (erysipelas), rosacea, shingles, and chronic psoriasis, as well as during pregnancy and lactation.
Adverse side effects include:
LD50 (mouse, oral): >4000 mg/kg
LD50 (Maus, subkutan): 180 mg/kg
LD50 (Maus, intraperitoneal): 450 mg/kg
Markus Falkenstätter, BSc
Mag. pharm. Stefanie Lehenauer
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