| ATC Code | N02CC07 |
| CAS number | 158747-02-5 |
| PUB number | 77992 |
| Drugbank ID | DB00998 |
| Empirical formula | C14H17N3O |
| Molar mass (g·mol−1) | 243,394 |
| Physical state | solid |
| Density (g·cm−3) | 1,3 |
| Boiling point (°C) | 515,2 |
| PKS value | 14,54 |
| Solubility | 0.123 mg/mL |
Frovatriptan is an active ingredient for the acute treatment of migraine attacks. It is a vasoconstrictive agent and belongs to the group of triptans. It is available in tablets and is usually in the form of frovatriptan succinate monohydrate. It is also a white powder that is soluble in water. Frovatriptan is an indole derivative that is structurally related to serotonin.
Frovatriptan acts by binding to the 5-HT receptor, specifically the 5-HT1B and 5-HT1D receptors. It has an effect on extracerebral and intracranial blood vessels. It is said to prevent swelling (dilation) of the blood vessels and also the release of inflammatory mediators. The pathology behind migraine is presumably a swelling of the blood vessels in the brain. Frovatriptan is designed to prevent this swelling by constricting the blood vessels (vasoconstriction).
Frovatriptan is metabolized (converted) in the liver, mainly via the CYP1A2 enzyme. The bioavailability, i.e. the percentage of the active substance that is available in the blood, is 20-30%. The half-life, i.e. the time the body needs to excrete half of the active substance, is around 26 hours.
Always take frovatriptan exactly as described in the package leaflet or as advised by your doctor.
The usual recommended dose for a migraine attack is 2.5 mg. If the symptoms have improved only slightly after 2 hours or have reappeared, 2.5 mg can be taken again.
The maximum dose is 7.5 mg in 24 hours .
Frovatriptan should not be taken more often than a maximum of 4 migraine attacks per month, as otherwise it can no longer be taken safely.
The following side effects may occur:
Frequent:
Occasionally:
Rarely:
Frequency unknown:
Interactions may occur if the following medicines are taken at the same time:
Frovatriptan must NOT be taken in the following cases:
Frovatriptan is approved for use from the age of 18 .
Frovatriptan should NOT be taken during pregnancy and breastfeeding, as there are almost no reports or studies available.
24 hours after taking frovatriptan, you should NOT breastfeed or discard your milk.
Sumatriptan can be used as an alternative during both pregnancy and breastfeeding.
Thomas Hofko
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