| ATC Code | M01AB16, M02AA25 |
| CAS number | 89796-99-6 |
| PUB number | 71771 |
| Drugbank ID | DB06736 |
| Empirical formula | C16H13Cl2NO4 |
| Molar mass (g·mol−1) | 354,185 |
| Physical state | solid |
| Density (g·cm−3) | 1,5 |
| Melting point (°C) | 149 |
| Boiling point (°C) | 486 |
| PKS value | 3,44 |
| Solubility | 0.00199 mg/mL |
Aceclofenac is an active ingredient for the treatment of pain and inflammation. It belongs to the prominent group of NSAIDs - non-steroidal anti-inflammatory drugs, which also includes ibuprofen and aspirin. Aceclofenac is structurally related to diclofenac, also an NSAID. Aceclofenac appears to have a stronger anti-inflammatory effect than other NSAIDs.
Like other NSAIDs, aceclofenac works by inhibiting the enzymes cyclooxygenase I & II (COX-1 and COX-2). These two enzymes are significantly involved in inflammatory reactions. Cyclooxygenases 1 & 2 are responsible for the formation of inflammatory mediators. Inflammatory mediators are substances that influence inflammatory reactions. These include prostaglandin E2 (PGE2), cytokines, interleukins and tumor necrosis factors.
Aceclofenac is broken down by the liver and excreted in the urine. The bioavailability of aceclofenac, i.e. the percentage of the active substance that is available in the blood, is 60%. The half-life, i.e. the time the body needs to excrete half of the active substance, is 4 hours. The maximum plasma concentration (Cmax), i.e. the maximum concentration of the active substance in the blood plasma (liquid cell-free part of the blood), is reached after 1.25-3 hours.
Always take aceclofenac exactly as described in the package leaflet or as advised by your doctor.
The usual recommended dose is 100 mg daily. The maximum daily dose should not exceed 200 mg .
The following side effects may occur:
Frequent:
Occasionally:
Rarely:
Very rare:
Interactions may occur if the following medicines are taken at the same time:
Aceclofenac must NOT be taken in the following cases:
Aceclofenac should only be used from the age of 18 .
During pregnancy, Aceclofenac should only be taken up to the 28th week of pregnancy after consultation with your doctor. Aceclofenac should NOT be taken after the 28th week of pregnancy.
No increased risk of malformation has been reported in the 1st trimester of pregnancy.
In the 2nd and 3rd trimester (especially from the 28th week of pregnancy), the ductus arteriosus botalli in the unborn child may become blocked, which can lead to damage to kidney function. Taking it after the 28th week of pregnancy can also lead to numerous health problems in the newborn, such as persistent pulmonary hypertension (PPHN) or nectrotizing enterocolitis (NEC). An alternative is paracetamol, which can be used throughout pregnancy.
Aceclofenac should NOT be used during breastfeeding as it can pass into breast milk. An alternative is paracetamol.
Aceclofenac was developed in 1991 by chemically modifying diclofenac. Aceclofenac causes less gastrointestinal discomfort as a result of the modification, which was the aim of the development.
Thomas Hofko
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