Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.
Dosage
<10 mg>
The recommended dose of Memantine Synthon for adults and elderly patients is 20 mg once a day.
In order to reduce the risk of side effects this dose is achieved gradually by the following daily treatment scheme:
| week 1 | half a 10 mg tablet |
| week 2 | one 10 mg tablet |
| week 3 | one and a half 10 mg tablet |
| week 4 and beyond | two 10 mg tablets once a day |
The recommended dose can also be achieved by using a treatment initiation pack.
The usual starting dose is half a tablet once a day (1x 5 mg) for the first week. This is increased to one tablet once a day (1x 10 mg) in the second week and to 1 and a half tablet once a day in the third week. From the fourth week on, the usual dose is 2 tablets once a day (1x 20 mg).
<20 mg>
The recommended dose of Memantine Synthon for adults and elderly patients is 20 mg once a day.
In order to reduce the risk of side effects this dose is achieved gradually by the following daily treatment scheme. For up-titration other tablet strengths are available.
At the beginning of treatment you will start by using Memantine Synthon 5 mg film-coated tablets once a day. This dose will be increased weekly by 5 mg until the recommended (maintenance) dose is reached. The recommended
| issue date: 03-09-13 | version: M1.3.1_03.MMN.hcl.tab.101.03.NL.2697.01 | approved: CHo |
Common Technical Document
Memantine HCl
Film-coated tablets
| Module 1 - Section 3.1 SPC, Labelling | |
| and Package Leaflet | page 5/10 |
maintenance dose is 20 mg once a day, which is reached at the beginning of
the 4th week.
<treatment initiation pack>
The recommended treatment dose of 20 mg per day is achieved by a gradual increase of the Memantine Synthon dose during the first 3 weeks of treatment. The treatment scheme is also indicated on the treatment initiation pack. Take one tablet once a day.
Week 1 (day 1-7):
Take one 5 mg tablet once a day (yellow, oval, biconvex) for 7 days.
Week 2 (day 8-14):
Take one 10 mg tablet once a day (white, round, biconvex) for 7 days.
Week 3 (day 15-21):
Take one 15 mg tablet once a day (orange-brown, round, biconvex) for 7 days.
Week 4 (day 22-28):
Take one 20 mg tablet per day (pink, oval, biconvex) for 7 days.
| week 1 | 5 mg tablet |
| week 2 | 10 mg tablet |
| week 3 | 15 mg tablet |
| week 4 and beyond | 20 mg tablets once a day |
Maintenance dose
The recommended daily dose is 20 mg once a day.
For continuation of the treatment, other tablet strengths are available. Please consult your doctor.
Dosage in patients with impaired kidney function
If you have impaired kidney function, your doctor will decide upon a dose that suits your condition. In this case, monitoring of your kidney function should be performed by your doctor at specified intervals.
<10 mg>
Breaking the tablet
Place the tablet with the round side on a hard surface, the score line should face upwards. Press with the forefinger and thumb of the same hand on either side of the score line and push down until the tablet breaks as shown in the illustration.
| issue date: 03-09-13 | version: M1.3.1_03.MMN.hcl.tab.101.03.NL.2697.01 | approved: CHo |
Common Technical Document
Memantine HCl
Film-coated tablets
| Module 1 - Section 3.1 SPC, Labelling | |
| and Package Leaflet | page 6/10 |
<20 mg>
Breaking the tablet
Place the tablet with the round side on a hard surface, the score line should face upwards. Press with the forefinger and thumb of the same hand on either side of the score line and push down until the tablet breaks as shown in the illustration.
Administration
Memantine Synthon should be administered orally once a day. To benefit from your medicine you should take it regularly every day at the same time of the day. The tablets should be swallowed with some water. The tablets can be taken with or without food.
Duration of treatment
Continue to take Memantine Synthon as long as instructed by your doctor. He will assess your treatment on a regular basis.
If you take more Memantine Synthon than you should
In general, taking too much Memantine Synthon should not result in any harm to you. You may experience increased symptoms as described in section 4, Possible side effects.
If you take a large overdose of Memantine Synthon, contact your doctor or get medical advice, as you may need medical attention.
If you forget to take Memantine Synthon
| issue date: 03-09-13 | version: M1.3.1_03.MMN.hcl.tab.101.03.NL.2697.01 | approved: CHo |
Common Technical Document
Memantine HCl
Film-coated tablets
| Module 1 - Section 3.1 SPC, Labelling | |
| and Package Leaflet | page 7/10 |
If you have forgotten to take your dose of Memantine Synthon, wait and take your next dose at the usual time.
Do not take a double dose to make up for the forgotten dose.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
